@CaptainDangernoodle It makes no difference at all. This is because Trading 212 has no fee on currency conversion. So it will cost you the same in GBP to buy 1 share of either version. Subsequently that 1 share will always be worth the same in GBP. The dividends will also be worth the same in GBP. Taxes will be the same in GBP. If you think about it this makes sense. That one share of VUSA represently fractional holdings in all the constituents of the S&P 500. Your returns will depend on how their prices move. It is like saying that to walk from home to the postbox takes the same energy no matter if you measure it in meters or yards. Note that VUSA and VUSD are actually the same fund, with a single ISIN.
The reason that the two versions exist is to serve those investors who do not have access to fee free currency conversion between USD and GBP and so may find it less costly to deal in one or other currency.
The same is true for the two version of Physical Gold. If your base currency is GBP then it makes sense to choose that version. You can rest assured that you are not missing out on some benefit you might have obtained with the VUSD, or indeed with VUSA.DE (the euro denominated version).
I wrote about this once before.